Active ingredients imidacloprid, permethrin and pyripoxyfen kill fleas, ticks and mosquitoes.Imidacloprid, permethrin and pyriproxyfen, the active ingredients in K9 Advantix II for dogs, spread over your dog’s skin to kill and repel fleas, ticks and mosquitoes, repel biting flies and kill lice. | Unlike some competitors, K9 Advantix II kills and repels mosquitoes.Frontline Plus doesn’t kill or repel mosquitoes. K9 Advantix II kills and repels fleas, ticks and mosquitoes that can spread diseases. | Fleas and ticks can impact pets in winter. Use K9 Advantix II monthly for year-round protection.Despite common misconceptions, fleas and ticks can impact pets even in colder months. Use K9 Advantix II monthly, year-round, for effective protection against fleas and ticks. |